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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IRAK2
All Species:
15.45
Human Site:
S521
Identified Species:
37.78
UniProt:
O43187
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43187
NP_001561.3
625
69433
S521
G
L
S
E
G
T
G
S
S
S
N
T
P
E
E
Chimpanzee
Pan troglodytes
XP_516275
594
65626
A497
Q
E
V
C
G
S
V
A
A
V
E
E
R
L
R
Rhesus Macaque
Macaca mulatta
XP_001090790
625
69610
S521
G
L
S
E
G
T
G
S
S
S
N
T
P
E
E
Dog
Lupus familis
XP_541772
619
68546
S517
G
L
S
E
G
T
S
S
S
S
N
T
P
E
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8CFA1
622
69028
S518
R
V
S
E
A
T
G
S
S
S
N
T
P
E
E
Rat
Rattus norvegicus
Q4QQS0
624
69218
S521
V
S
E
D
T
G
S
S
S
N
T
P
E
E
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519983
243
26550
I146
E
K
L
V
A
K
E
I
C
N
K
Y
L
E
K
Chicken
Gallus gallus
NP_001025776
691
76730
T544
T
S
G
F
S
M
N
T
P
E
E
T
D
D
E
Frog
Xenopus laevis
NP_001079489
672
75642
E522
P
E
E
S
D
F
E
E
S
L
S
F
E
P
T
Zebra Danio
Brachydanio rerio
XP_697688
686
76453
A502
T
I
N
K
S
P
V
A
T
P
E
P
L
R
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.9
94.5
80.3
N.A.
69.5
71.1
N.A.
22
40.2
35.5
28.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
94.4
96.8
86
N.A.
81.1
83
N.A.
30
56.1
52.2
50
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
100
93.3
N.A.
80
20
N.A.
6.6
13.3
6.6
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
26.6
100
93.3
N.A.
86.6
33.3
N.A.
20
26.6
13.3
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
20
0
0
20
10
0
0
0
0
0
0
% A
% Cys:
0
0
0
10
0
0
0
0
10
0
0
0
0
0
0
% C
% Asp:
0
0
0
10
10
0
0
0
0
0
0
0
10
10
0
% D
% Glu:
10
20
20
40
0
0
20
10
0
10
30
10
20
60
50
% E
% Phe:
0
0
0
10
0
10
0
0
0
0
0
10
0
0
0
% F
% Gly:
30
0
10
0
40
10
30
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
10
0
0
0
0
0
10
0
0
0
0
0
0
0
% I
% Lys:
0
10
0
10
0
10
0
0
0
0
10
0
0
0
10
% K
% Leu:
0
30
10
0
0
0
0
0
0
10
0
0
20
10
0
% L
% Met:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
0
0
0
10
0
0
20
40
0
0
0
0
% N
% Pro:
10
0
0
0
0
10
0
0
10
10
0
20
40
10
0
% P
% Gln:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
10
0
0
0
0
0
0
0
0
0
0
0
10
10
10
% R
% Ser:
0
20
40
10
20
10
20
50
60
40
10
0
0
0
10
% S
% Thr:
20
0
0
0
10
40
0
10
10
0
10
50
0
0
20
% T
% Val:
10
10
10
10
0
0
20
0
0
10
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _